Researchers employ several techniques to investigate the aetiology of thousands of medical illnesses. One such technique is the use of mice or rats as models. Often, attempting to directly research the pathophysiology of a variety of medical problems in humans is difficult. The hazards and consequences of this research can be exceedingly serious and even fatal. This is where researchers turn to alternate methodologies, such as mice or rat models, to elucidate the medical condition’s intricacies. Additionally, this enables them to determine which regions of the human body they should target to treat the ailment and the efficacy of a certain treatment method.
While various studies are being conducted in this area, one of the most critical focuses is rheumatoid arthritis. Researchers are attempting to understand the pathogenesis of rheumatoid arthritis and identify JustCBD products that can help alleviate its symptoms, such as pain relief sprays, pain relief roll-ons, CBD body oils, pain relief creams, and pain relief oils, capsules, pills, and nasal sprays. In this example, the researchers employ collagen-induced arthritis to produce arthritis in a rat or mouse model.
What is the collagen-induced rheumatoid arthritis mouse model? How does it contribute to rheumatoid arthritis pathogenesis? And, more importantly, how effective are CBD products in treating this condition? Let us examine the same in further detail.
CBD oil and pain alleviation in rheumatoid arthritis
In the United States, arthritis is the biggest cause of disability, impacting approximately 54.4 million individuals. Rheumatoid arthritis is an autoimmune disease in which the immune system assaults joints, resulting in inflammation. It is most frequently found in the hands and feet, causing painful, swollen, and stiff joints.
Osteoarthritis is a degenerative disorder that damages the cartilage and bones of the joints, resulting in pain and stiffness. It frequently manifests in the hip, knee, and thumb joints.
According to the Arthritis Foundation, there is anecdotal evidence that some patients who use CBD report considerable pain alleviation, increased sleep, and decreased anxiety. However, they also acknowledge that “no robust clinical investigations” in individuals with arthritis have been conducted to substantiate this. Therefore, the group has requested the Food and Drug Administration (FDA) to research and regulate CBD products.
Several animal studies show that CBD may be useful in treating arthritis and relieving related inflammatory pain. For instance:
- A report published in 2017: According to Trusted Source, CBD may be a safe and effective therapy choice for osteoarthritis-related joint discomfort.
- A 2016 study indicated that topical CBD administration could alleviate pain and inflammation associated with rheumatoid arthritis.
- According to a 2014 evaluation of the existing animal studies, CBD may be an effective therapy for osteoarthritis.
- CBD was discovered to help lessen inflammatory pain in rats in a 2011 study trusted Source by altering how pain receptors respond to stimuli.
- However, there is a shortage of scientific evidence unequivocally demonstrating that CBD is viable for human arthritis.
Research conducted in 2006
According to Trusted Source, a cannabis-based mouth spray called Sativex assisted in relieving arthritic discomfort. However, the company’s cannabis plant extracts are used to create the spray containing both CBD and THC.
While preliminary data are encouraging, further study is needed to establish that CBD oil is effective for rheumatoid arthritis pain.
How to Choose the Appropriate CBD Product for You ?
CBD is available almost everywhere, from supermarkets and pharmacies to health food stores and internet vendors. However, how can you find the best CBD product for your specific health requirements?
1.Decide on the CBD formulation that you wish to use.
CBD is available in a variety of forms. Among the most often used are:
- CBD-infused edibles include candy, chocolates, drinks, baked products, and other edibles.
- Vaporizer: CBD is inhaled using a vape pen, which warms the oil.
- Drops sublingual: You place a few drops of a high-concentrate CBD solution beneath your tongue.
- Topicals: These include creams, lotions, balms, and other items containing CBD that you apply directly to your skin.
The various forms of CBD exert their effects on your body at varying speeds. According to Dr Damas, the duration of action for various types of CBD products is as follows:
- 30 minutes to two hours for edibles
- Two minutes with the vaporizer
- 15-30 minutes for sublingual drops
- Topical discussions: ten minutes
2.Search for Indicators of High-Quality CBD
Avoid purchasing the cheapest item on the shelf. Several low-quality CBD products are on the market (some of which, according to these FDA warning letters, do not contain the claimed quantity of CBD). Dr Damas advises consumers to seek CBD products that are manufactured in the United States, utilize a carbon dioxide-based extraction technology (“it’s the purest,” he adds), are derived from organically cultivated hemp, and are free of unnecessary additives. Additionally, Consumer Reports provides a comprehensive guide to purchasing CBD that will assist you in locating a high-quality product.
3.Determine the Appropriate Dose
The judgment is still out on how much you should take when it comes to CBD oil dose. Begin with a modest dose (between 5 and 10 mg) and gradually increase it over many weeks until you detect an impact.
“Typically, individuals have pain alleviation when they take between 20 and 35 milligrammes of CBD daily,” Dr Damas explains.
You may take the entire amount at once or spread it out over the day. Experiment to discover what makes you the happiest. You should begin to see benefits quickly after CBD supplementation, with more visible results occurring within two weeks.
If you’re considering CBD treatment for persistent arthritic pain or are already using it, discuss the benefits, drawbacks, and newest research with your healthcare professionals so that you can collaborate on a suitable treatment plan. Depending on the type of arthritis you have, it may be critical to continue taking your conventional prescription drugs in addition to CBD products.
While we may not have all of the proof we need, if CBD may safely alleviate your symptoms, it is worth trying.